L. Antonio-Gutierrez, J. Gracia-Mora, M. and J. Bernad-Bernad
National Autonomous University of Mexico, Mexico
Posters & Accepted Abstracts: J Formul Sci Bioavailab
Statement of the Problem: Cancer is an illness present in the whole world, only in 2015, it registered 8,8 million
people died because of this disease. Nowadays the chemotherapeutic remains like the most popular treatment.
However, it is not selective and usually, bring with its multifold side effects which decrease the patient�??s quality
of life. For this reason, is searched to develop drug delivery systems which let the drug release in the target site
decreasing in this form dose and side effects. One of the most promising drug delivery systems are the systems based
on the hybrid of molecularly imprinted polymers (MIP´s) with magnetic nanoparticles as magnetite (Fe3O4). The
magnetic molecularly imprinted polymers (MMIP´s) combine the magnetic properties from nanoparticles with the
high capacity of recognize from MIP´s in an only hybrid structure functional which let to obtain a system whose
drug delivery is only in the target site improving the drug efficiency and resulting in a reduction of the side effects
on normal tissues. In this work is presented the synthesis and characterization of a magnetic MIP system for the
selective recognition of the antitumoral drug 6-mercaptopurine and its evaluation as a drug delivery system.
Methodology: The synthesis of magnetite nanoparticles has been carried out by the coprecipitation method. The
particles were coated with the polymer by non-covalent molecularly imprinted technique, four different functional
monomers were evaluated. The systems were characterized and carried it out the adsorption studies. Finally, the in
vitro release of 6-mercaptopurine was studied evaluating the effect of the magnetic hyperthermia with alternating
magnetic field.
Conclusion: The magnetic nanoparticles were successfully coated with different polymers. Differences in the amount
of drug adsorbed were observed in the different systems showing all these Isotherms like Langmuir-Freundlich. The
evaluation of drug release showed differences when the systems were exposed under an alternate magnetic field.
Recent Publications
1. Organization), W. W. H. Cancer,
2. Allen, T. M. & Cullis, P. R. Drug Delivery Systems: Entering the Mainstream. Science 303, 1818-1822,
doi:10.1126/science.1095833 (2004).
3. Yin, Q., Shen, J., Zhang, Z., Yu, H. & Li, Y. Reversal of multidrug resistance by stimuli-responsive drug
delivery systems for therapy of tumor. Adv. Drug Deliv. Rev 65, 1699-1715, doi:https://doi.org/10.1016/j.
addr.2013.04.011 (2013).
4. Kubo, T. et al. Magnetic Field Stimuli-Sensitive Drug Release Using a Magnetic Thermal Seed Coated with
Thermal-Responsive Molecularly Imprinted Polymer. ACS Biomaterials Science and Engineering 5, 759-767,
doi:10.1021/acsbiomaterials.8b01401 (2019).
5. Dinc, M., Esen, C. & Mizaikoff, B. Recent advances on core�??shell magnetic molecularly imprinted polymers
for biomacromolecules. TrAC - Trends in Analytical Chemistry 114, 202-217, doi:10.1016/j.trac.2019.03.008
(2019).
Leticia Antonio is a student of the master’s in chemicals sciences of the National Autonomous University of Mexico, UNAM. Her investigation project is focused on the study of magnetic molecularly imprinted polymers as a drug delivery system for the treatment of cancer. In order to improve the efficiency in the coating, she is evaluating a new method of synthesis using the magnetic hyperthermia.
Journal of Formulation Science & Bioavailability received 23 citations as per Google Scholar report
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