Synthesis and characterization of azolyl-acetic acids and azolyl-β-hydroxyacetamides assisted by microwave irradiation

18^th International Conference on Medicinal Chemistry & Targeted Drug Delivery

December 06-08, 2017 Dallas, USA

Juan Alberto Reyna Torres, Gladiola Noemi Machuca Perez, Veronica M Rivas Galindo, Perla Elizondo Martinez and Eugenio Hernandez Fernandez

Universidad Autonoma de Nuevo Leon, Mexico

Posters & Accepted Abstracts: Med Chem (Los Angeles)

Abstract :

Easy and efficient synthesis of compounds with biological activity are of great interest due to health problems worldwide. Reason why diverse groups of investigation dedicate their efforts to develop new strategies of synthesis to accede to new compounds of a fast and efficient way. In this sense, the synthesis of azolyl-acetic acids and azolyl-�²-hydroxyacetamides assisted by microwave irradiation is a unique methodology that allows to obtain these kind of compounds with better chemical yields, in little time of reaction and use of reagents more friendly with the environment. In this work, five azolyl-esters 3a-e were obtained by reaction between the corresponding azole 1a-d with ethyl bromoacetate 2, by ultrasound. Subsequently, with the compounds pure in hand, the hydrolysis reaction was carried out under microwave irradiation between the azolyl-esters 3a-e in the presence of K2CO3 and ethanol as solvent, to generate azolyl-acetic acids 4a-e. On the other hand, the amidation reaction of azolyl-esters 3a-e with ethanolamine using microwave irradiation and solvent free, generated the azolyl-�²-hydroxyacetamides 5a-e. All compounds were characterized by infrared spectroscopy (FT-IR), Nuclear Magnetic Resonance 1H, 13C (NMR 1H, 13C) and High Resolution Mass Spectrometry (HRMS).

Biography :

Juan Alberto Reyna Torres is ninth semester student of the Facultad de Ciencias Químicas at the Universidad Autónoma de Nuevo León