Synthesis, characterization and anticancer activity of transition metal complexes derived by tridentate ligands 4-amino-1, 2-naphthoquinone-2-thiosemicarbazone and 4-amino-1, 2-naphthoquinone-2-semicarbazone

2^nd International Conference on Medicinal Chemistry & Computer Aided Drug Designing

October 15-17, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

Radhey Shyam Srivastava, Shubhanjali Shukla, Sushant Kumar Shrivastava1, Ritu Joshi, Sairam Krishnamurthy, Ajit Sodhi and Pankaj Kumar

Posters: Med chem

Abstract :

A series of transition metal complexes of Co(II), Ni(II) and Cu(II) have been synthesized with novel ligands 4-amino-1,2- naphthoquinone-2-thiosemicarbazone and 4-amino-1,2-naphthoquinone-2-semicarbazone. The structures of the complexes were established by spectroscopic data i.e. UV, IR, 1HNMR, 13CNMR, Mass, ESR, magnetic measurements and elemental analysis. The results suggested that Co(II) and Ni(II) complexes posses 1:2 metal to ligand stoichiometry, while the Cu(II) complexes exhibit 1:1 metal-ligand compositions. Compounds have been evaluated for in-vitro antiproliferative activity against three human cancer cell lines viz. MCF-7 for human breast cancer, Hep-G2 for liver carcinoma and MG-63 for osteosarcoma using MTT assay, and in-vivo anticancer activity on MNU induced breast cancer animal model. Results of antiproliferative screening revealed that, metal complexation enhanced the cytotoxicity of ligands in all cancer cells and Cu complexes were found to be most active compounds of the series in both in-vitro and in-vivo anticancer studies. Keywords: Transition metal complexes, MCF-7, Hep-G2, MG-63, antiproliferative activity, MTT assay.