Synthesis, characterization and catalytic applications of new monodentate N-alkylpyridin-4 (1H)ylidene) amines (PYE) ligands

International Conference and Exhibition on Materials Chemistry

March 31-April 01, 2016 Valencia, Spain

Sabeen Zahra

University of Gujrat, Pakistan

Posters & Accepted Abstracts: J Material Sci Eng

Abstract :

The present study describes the synthesis, characterization and applications of protonated pyridinium amide (H-PYE) and pyridinium amide (PYE) ligands itself. H-PYE ligands [HL1-HL4] were synthesized by a solid state reaction between 4-chloro- N-methyl pyridinium triflate and corresponding amines at 220�°C. PYE ligands [L1-L4] were synthesized by deprotonation of the H-PYE ligands with sodium hydride in dichloromethane solvent. Both H-PYE and PYE ligands were characterized by physical parameters, FT-IR, 1H and 13C NMR and mass spectrometry. The role of pyridinium amide ligands towards Suzuki-Miyaura and Heck-Mizoroki coupling reactions in the presence of Pd (OAc)2 was monitored and achieved remarkable results. The antioxidant activity of synthesized ligands was observed by scavenging method of DPPH radical and ligands exhibited significant activity. The biological activities of synthesized compounds were tested against four bacterial and two fungal strains and results indicated that only [HL4] displayed antibacterial activity with Chromohalobacter israelensi while both H-PYE and PYE showed minor antifungal activity with one of the strain Aspergillus niger. Enzyme inhibition activity of the ligands was performed against two enzymes i.e. acetylcholine esterase and butyrylcholin esterase. The results specified that ligands presented good inhibition. Moreover, the DNA binding studies were achieved by using UV-Visible and fluorescence emission spectroscopy which revealed hypochromic effect indicating intercalation as well as groove mode of binding.

Biography :

Email: meen.yani@yahoo.com