Synthesis of 2, 3-disubstituted indoles via Pd-catalyzed tandem heteroanulation of α-diketones and N-arylamines under reductive conditions

2^nd World Chemistry Conference

August 08-10, 2016 Toronto, Canada

Pankaj Sharma

Instituto de Quimica, Mexico

Posters & Accepted Abstracts: Chem Sci J

Abstract :

Herein we report a new straight forward catalytic synthesis of N-substituted indoles from �±-diketones 1 and N-substituted anilines 2 by employing Palladium (II) complex and phosphine ligands under reductive conditions. The tandem reaction involves enamine and ketoamine as intermediates and final annulation-dehydration reaction to obtain the N-substituted indole. New Palladium-hydride species were observed in the NMR studies which catalyzes the reaction.This report constitutes a new regioselective route to synthesize indoles under reductive conditions. pankajsh@unam.mx