Synthesis of diosgenin containing m-PEG-PCL nanoparticles: Anticancer, antimicrobial and drug delivery studies

4^th International Conference on Polymer Chemistry

June 25-27, 2018 | Stockholm, Sweden

Sevinc Ilkar Erdagi

Kocaeli University, Turkey

Scientific Tracks Abstracts: J Material Sci Eng

Abstract :

Diosgenin is a steroidal saponin from a therapeutic herb. Natural products have always played a highly significant and potential role in the drug discovery. Here, we developed a nanoparticle platform based on poly(ethylene glycol)- poly(caprolactone)�diosgenin (mPEG-PCL�DGN) conjugates for co-delivery of anticancer drugs. Firstly, to improve the solubility and bioavailability of DGN, the amphiphilic conjugates mPEG-PCL-DGN were made by linking DGN with PCL and mPEG. Then they self-assembled nanoparticles to deliver another anticancer drug imatinib mesylate (ITB) by a simple nanoprecipitation method. The obtained nanoparticles possessed the appropriate size, high drug loading efficiency of diosgenin and ITB. In this study, polymer�drug conjugates mPEG�PCLDGN was synthesized based on PCL, mPEG, and diosgenin, in which diosgenin, PCL and mPEG were used as the hydrophobic and the hydrophilic segment, respectively. Then the mPEG� DGN self-assembled into a polymeric nanoparticle with linear PCL, mPEG, and diosgenin (Figure). The nanoparticles were developed as an important strategy for drug delivery due to their capabilities of enhancing drug solubility.

Biography :

Sevinc Ilkar Erdagi is pursuing her PhD in Kocaeli University, Turkey under supervision of Prof. Dr. Ufuk Yildiz. She is a Research Assistant in Kocaeli University for seven years. She studies Organic Chemistry and Polymer Chemistry especially in steroid chemistry and natural products.

E-mail: sevinc.ilkar@kocaeli.edu.tr