Synthesis of novel thiazolidinedione derivatives and evaluation of their antiviral activity

Joint Event on 23^rd International Conference on Advanced Materials & 10^th International Conference on Chemistry Education and Research

June 20-22, 2018 Oslo, Norway

Basant M Saleh

Zagazig University, Egypt

Posters & Accepted Abstracts: J Chem Sci

Abstract :

We previously identified one large molecular structure targeting the HIV-1 gp41, 2-Aryl 5-(4-Oxo-3-phenethyl-2- thioxothiazolidinylidenemethyl) furan, which acts as lead compound for our novel synthetized drugs. On the basis of molecular docking analysis, we designed a series of -5-benzylidene-3-phenethylimidazolidine-2,4-dione. Novel thiazolidinedione derivatives were synthesized starting from hydantoin and thiohydantoin. 5-benzylidene-3-phenethylimidazolidine-2,4-diones were synthetized by alkylation followed by a Knoevenagel condensation and tested for their anti-HIV-1 activity and cytotoxicity on MT-2 cells. The synthesized compounds were characterized by 1H NMR, 13C NMR, mass spectroscopy, high resolution mass spectroscopy, IR and physical data.