mmer Faruk COL
Gazi University, Turkey
Posters & Accepted Abstracts: Med chem
The hydrolysis of acetylcholine (ACh) which is a significant neurotransmitter for regulation of cognition in humans is the main task of AChE in cholinergic synapses. ACh level rises in the cholinergic synapses when these enzymes are inhibited. Thus, cholinesterase inhibitors are used in the treatment of various neuromuscular disorders which occur as a result of reduced cortical and hippocampal levels of ACh, such as Alzheimer�¢����s disease (AD) is a progressive neurodegenerative disorder characterized by synapse dysfunction, neuronal death, loss of memory and learning ability. Many researchers have synthesized hydrazone compounds as target structures and evaluated their biological activities. Hydrazones have been reported to possess, antibacterial, antifungal, antitubercular, antiviral and antimalarial activities. In this context, we synthesized new 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/ nonsubstituted benzalhydrazone) in order to investigate their in vitro AChE/BChE inhibitory activities by using the Ellman�¢����s method. Compounds have been synthesized starting from substitue/nonsubstitue acetophenon. 6-(4 substitue/nonsubstituephenyl)-3(2H)- pyridazinone was obtained from reaction of acetophenon with succinic anhydrate. Ester derivatives were obtained from the reaction of the resulting pyridazinone compound with propyl bromoacetate. After that acetohydrazide derivatives were constituted by reaction of these ester derivative compounds with hydrazine hydrate and the acetohydrazides were changed to title compounds which have benzalhydrazone structure by using substitue/nonsubstitue benzaldehydes. Their structures were confirmed by IR, 1H-NMR, 13C-NMR and mass spectral analysis data.
Email: mgokce44@gmail.com
Medicinal Chemistry received 6627 citations as per Google Scholar report
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