Synthesis of some new derivatives of indolyl quinazoline systems

19^th Global Chemistry, Chromatography & Spectrometry Conference

March 20-21, 2019 | New York, USA

Akaki Kalatozishvili

Ivane Javakhishvili Tbilisi State University, Georgia

Posters & Accepted Abstracts: Chem Sci J

Abstract :

The experience indicates that most of ingredients of medicine are heterocycles. Among them heterocyclic compounds containing nitrogenatom are very important. Many therapy medicines have been made based on them, such as: indole, indometacine, rezerpine, indopane, pirazidole, meksamine and etc. [1]. Quinazoline derivatives are used in treatment of leukemia, malaria or bacterial infections [2]. 2, 4-Diaminoquinazoline derivatives [3] have also active properties like antimicrobial, antiviral and fungicidal. Pharmaceuticals like methotrexate, trimethoprim, piritrexim and iclaprim contain 2, 4-diaminoquinazoline moieties as well [2]. Our goal was to synthesize of new derivatives of indolylquinazoline system and study their pharmacological activities. Target compounds 7-9 were sinthesized by condesation of 2-(p-aminophenyl)indoles 1-3 with sodium dicianamide and their 4-6 further intramolecular cyclization in PPA with 50-55% yield.

Biography :

E-mail: kako_kala@yahoo.com