Synthesis of some novel N-(6-substituted benzothiazole-2-yl)-2-(4-substituted piperazin-1-yl) asetamide derivatives and evaluation their anticancer activity

2^nd International Conference on PHARMACEUTICAL CHEMISTRY

October 02-04, 2017 Barcelona, Spain

B�¼sra Ekselli, G�¼lsen Akal�±n-Ciftci, Asaf Evrim Evren And Leyla Yurttas

Anadolu University, Turkey
Anadolu University, Turkey.

Posters & Accepted Abstracts: Med Chem (Los Angeles)

Abstract :

Cancer is the uncontrolled growth of cells combined with malignant behavior: invasion and metastasis and also is one of the most prevalent causes of death, after cardiovascular diseases.[1] Despite the increasing number of anticancer agents developed to date, the lack of selectivity and the getting of multiple-drug resistance account for significant problem for successful cancer treatment and therefore researchers have focused on the create of more specific and less toxic agents [1,2,3] Todays, cytotoxic drugs are used in a widespread because of raising in cancer incidence and one of the these drug groups is benzothiazole derivatives. [4] Benzothiazole derivatives have a wide spectrum of pharmaceutical applications such as anticancer antimicrobial, anticonvulsant, antiviral, antitubercular, antimalarial, analgesic, antiinflammatory, antidiabetic, antifungal, antibacterial, antioxidant activity and etc. [5] For these reasons, the aim of this study was to synthesize and investigate anticancer activity of some novel N-(benzothiazol-2-yl)piperazine-1-carboxamide derivatives (2a-l) The structural elucidation of the compounds was performed by 1H-NMR, 13C-NMR and LC-MS/MS spectral data and elemental analyses. The title compounds were obtained by reacting 2-chloro-N-(substituted benzothiazol-2-yl)acetamide with some piperazine derivatives. Twelwe new compounds are evaluating for determining their cytotoxicities against A549 human lung adenocarcinoma cell line and NIH/3T3 mouse embryonic fibroblast cell line.After that the selected compounds will be evaluated to identify apoptotic cell rates. Activity studies are still in progress. Keywords: Benzothiazole, Piperazine, Anticancer activiy,Apoptosis

Biography :

BüÃ?Â?ra EKSELLÃ?° has completed his BD (Bachelor Degree) at the age of 22 years from Anadolu University,Pharmacy Faculty and she is still postgraduate student at Anadolu University, Department of Biohemistry.