TBARS and hematological parameters unveil in breast cancer patients

3^rd World Congress on Women’s Health & Breast Cancer

October 03-05, 2016 London, UK

Shweta Suman

Jiwaji University, India

Posters & Accepted Abstracts: J Cancer Sci Ther

Abstract :

Breast cancer is one of the most influencing cancers, which led to 458,503 deaths worldwide in 2008 (13.7% in women and 6.0% of all cancer deaths for men and women together). Over the last few decades the risk of breast cancer among Indian women has increased suddenly. Breast cancer occurs in breast tissues, consisting glands of milk producing tissues, the lobules, and the ducts connecting those lobules to the nipple. The present experiment aims to investigate the (malon dialdehyde) MDA level in different grades of breast cancer patients. Reactive oxygen species (ROS) are free radicals and are chemically reactive. Reactive oxygen species can damage tissues, leading to oxidative stress and ultimately cell death. Lipid peroxidation (LPO) involves ROS stimulated oxidation and degeneration of polyunsaturated fatty acid (PUFA), producing MDA. During pathogenesis or changes in biological activities, free radicals are generated in mitochondria at the time of electron transport chain which react with other biomolecules (DNA, protein, lipid) to produce unstable products. From the present study it was revealed that, RBC count was higher (3.9092Ã?Â?106/mm3) in Grade II than Grade I followed by Grade III, which was lower than the normal one, WBC count (10.44Ã?Â?103/mm3) in Grade III was higher than Grade I and Grade II respectively, however the Platelets count was (244.6Ã?Â?103/mm3) was significantly lower than the normal value and the hemoglobin (11.69 g/dl), in grade I was higher than Grade II and Grade III respectively.

Biography :

Email: sumanshweta92@gmail.com