Ten-year outcome study in a cohort of non-metastatic renal cell carcinoma treated with curative intent at SKCH and RC: Survival and progression after radical nephrectomy in 344 patients

13^th Annual Conference on Nephrology & Renal Care

May 24-25, 2018 Tokyo, Japan

Nouman Khan, Arshad Irshad Khalil, Sidra Manzoor, Komal, Azfar Ali, Usman Ahmad, Irfan Ahmad and Khurrum Mir

Shaukat Khanum Memorial Cancer Hospital & Research Centre, Pakistan

Scientific Tracks Abstracts: J Nephrol Ther

Abstract :

Background: Radical Nephrectomy (RN) is a standard treatment of cure for Non-Metastatic Renal Cell Carcinoma (NMRCC). Long-term outcome data are limited for Pakistani population. Our aim was to assess the long-term outcomes of RCC treated with curative intent with Radical Nephrectomy (RN). Objective: To study the 5 and 10 years outcomes in patients with NMRCC who underwent radical nephrectomy. Method: This is a retrospective analysis of prospectively collected data between February 2006 and December 2016. We included all the adult patients (ageâ�?¥18 years) with NMRCC from both genders irrespective of their histologic subtypes who underwent radical nephrectomy (RN) with a curative intent. The data were analyzed for overall survival and recurrence rates at 5 and 10 years using Kaplan-Meier survival analysis. Multivariate analysis was done using Cox-regression to identify risk factors associated with poor overall outcome in terms of recurrence and mortality. Result: 344 patients with 195 (55.5%) males and 149 (44.2%) females with a mean age of 53.5�?±14.1 years were followed for a mean follow-up of 31.1�?±26.77 months (range: 3-132 months), with 46 (13.4%) deaths. 49 (14.2%) cases had disease recurrence with 33 (9.5%) deaths from disease progression. The 5-year progression-free survival was 37% (95% CI: 49.04-72.76) with the median time to recurrence was 33 months (95% CI: 27.6-38.4) and the median overall survival was 103.7 months (95% CI: 95.7-111.7). The 5-year overall survival was 76.1% (95% CI: 75.2-77) while 10-year survival was 70.8%. There was a significant median survival difference for cases with and without recurrence (log-rank Ï�?2: 117.5, p<0.001, T stage, Fuhrmanâ�?�?s grade and early postoperative recurrence. Conclusion: Radical nephrectomy offers the best survival for non-metastatic renal cell carcinoma patients with excellent postoperative survival and progression-free profile.

Biography :

Nouman Khan is a Clinical Urooncology Fellow at Shaukat Khanum Memorial Cancer Hospital and Research Centre. He has worked as a Medial Specialist at Institute of Kidney Diseases and Transplant Hospital for a span of 7 months. His skills and areas of interest include surgery, general surgery and healthcare.
Email:dr_noumank@hotmail.com