The association between glomerular filtration rate and stroke in hypertensive patients in rural areas of China

6^th Annual conference on Clinical & Pediatric Nephrology

May 09-10, 2016 New Orleans, USA

Liqiang Zheng

Shengjing Hospital of China Medical University, China

Posters & Accepted Abstracts: J Nephrol Ther

Abstract :

Objectives: The present study is to explore the association between estimated glomerular filtration rate (eGFR) and stroke in hypertensive patients in rural areas of China. Methods: The prospective study was based on 3,711 hypertensive patients who were aged �35 years, free from cardiovascular diseases and had serum creatinine at baseline. eGFR was estimated using the chronic kidney disease epidemiology collaboration equation. Results: During a median follow-up of 4.9 years, 176 first ever strokes (98 ischemic, 75 hemorrhagic and 3 were unspecified strokes) occurred. We found no independent association between eGFR and risk of hemorrhagic stroke. In contrast, with decreasing eGFR, the risk of total and ischemic stroke strongly increased; the sex and age adjusted hazard ratios for overall and ischemic stroke were 3.34 (95% CI, 1.61 to 6.93) and 3.79 (95% CI, 1.33 to 10.81) for patients with eGFR<60 versus eGFR�90 ml/min/1.73 m2, respectively. In addition, patients with an eGFR of 60 to 90 relative to eGFR�90 ml/min/1.73 m2 had hazard ratios of 2.31 (95% CI, 1.53 to 3.51) and 3.24 (95% CI, 1.76 to 6.00) for overall and ischemic stroke after adjustment for sex and age, respectively. Adjustment for other cardiovascular factors only slightly attenuated the associations. Conclusions: The patients with decreased eGFR, also included those with eGFR range between 60 and 90 ml/min/1.73 m2, had an independently increased risk of overall and ischemic stroke in hypertensive patients in rural areas of China.

Biography :

Email: liqiangzheng@126.com