The associations of endocannabinoids and metabolites of adipose tissue in kidney transplant recipients

4^th Global Surgery and Transplantation Congress

October 03-04, 2016 Atlanta, USA

Daria Salata, Malgorzata Marchelek Mysliwiec, Tomasz Janus, Andrzej Ciechanowicz, Wojciech Brzoska, Natalia Marczuk, Elzbieta Cecerska-Heryc and Barbara Dolegowska

Pomeranian Medical University, Poland

Posters & Accepted Abstracts: J Transplant Technol Res

Abstract :

Endocannabinoids (EKB) influence the function of endocrine, nervous and immune system, as well as may modify metabolism of lipids, carbohydrates and adipose tissue. EKB may also participate in the development of inflammation, in adhesion, migration and apoptosis of inflammatory cells. The most well-known EKB are anandamide and 2-arachidonylglycerol. They are closely associated with abnormalities in the glucose/lipid metabolism which is deregulated in patients after transplantation.On the other hand, action of these lipids on immune or endothelial cells may play a crucial role in determination of allograft survival. EKB may inhibit migration of immune cells to the site of transplanted allograft. EKB seem to be a promising target of research, potentially leading to improvement of both -early- and long-term outcome of transplanted kidney allograft. Our study included 35 patients after kidney transplantation from Nephrology, Transplantology and Internal Diseases Departments of Pomeranian Medical University and 40 healthy-individuals as control. Blood were collected directly before and at 5-7 day after transplantation and plasma concentration of anandamide and 2-arachidonylglyceroland adipocytokines: adiponectin, leptin were analyzed. We also examined serum biochemical parametersand lipid profile. Serum NGAL, creatinine and eGFR were evaluated as well as marked the renal function. Our study i) supports the significance of selected endocannabinoids in the in kidney transplant recipients ii) highlights associations between endocannabinoids and adipocytokines in kidney transplant recipients iii) preliminarily characterizes the diagnostic potential of EKBin kidney transplantation. This study was supported by a grant awarded by the Polish National Science Center.

Biography :

Email: daria_salata@wp.pl