The effectiveness of non-uniform dose fractionation compared with the uniform dose fractionation radiotherapy for malignant tumors of various types of cancer cells

3^rd International Conference on Medical Physics & Biomedical Engineering

November 07-08, 2016 Barcelona, Spain

Aleksandr Meniailo

A. Tsyb Medical Radiological Research Centre, Russia

Posters & Accepted Abstracts: J Bioengineer & Biomedical Sci

Abstract :

Optimization of radiation therapy treatment scheme using mathematical modeling is one of the topical problems in modern radiation oncology. For these purposes, formalized description of dynamic processes in clinical radiobiology is used. This study examines the effectiveness of the non-uniform dose fractionation mode as compared with a uniform dose fractionation in the treatment of tumors with different cell types. Using mathematical models of tumor cells survivals, various scenarios of dose fractionation were examined. In our calculations, we used following delivery of uniform dose fractions (2 Gy/day) and non-uniform dose fractions (increasing fraction size up to 5 Gy/day). In both cases, the total dose D is 50 Gy, the treatment period T is five weeks. In our results, we have shown that when tumor has large volume of oxygenated cells the non-uniform fractionation has more efficiency compared with the uniform fractionation. In addition, the radioresistance of hypoxic cells has almost no impact on this efficiency. For tumors which has small fraction of oxygenated cells, the efficiency of non-uniform fractionation markedly decreases with increasing radioresistance of hypoxic cells. So, modern methods of mathematical and computer modeling in clinical radiobiology are effective tools for optimization of radiation therapy.

Biography :

Email: menyajlo@nrer.ru