The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1

International Conference and Exhibition on Marine Drugs and Natural Products

July 25-27, 2016 Melbourne, Australia

Juewon Kim

AmorePacific R&D Center, Republic of Korea

Posters & Accepted Abstracts: J Pharmacogn Nat Prod

Abstract :

Dehydroabietic acid (DAA) is a naturally occurring diterpene resin acid of confers, such as Pinus species (P. densiflora, P. sylvestris) and grand fir (A. grandis), and it induces various biological actions including antimicrobial, antiulcer and cardiovascular activities. The cellular targets that mediate these actions are largely unknown yet. In this report, we suggest that DAA is an anti-aging reagent. DAA has lifespan extension effects in C. elegans, prevents lipofuscin accumulation and prevents collagen secretion in human dermal fibroblasts. We found that these anti-aging effects are primarily mediated by SIRT1 activation. Lifespan extension effects by DAA were ameliorated in sir-2.1 mutants and SIRT1 protein expression was increased, resulting in the deacetylation of SIRT1 target protein PGC-1�±. Moreover, DAA binds directly to the SIRT1 protein independent of the SIRT1 substrate NAD+ levels. Through a molecular docking study, we also propose a binding model for DAA-SIRT1. Taken together, our results demonstrate that the antiaging effects are the first identified biological property of DAA and that the direct activation of SIRT1 enzymatic activity suggests the potential use of this natural diterpene or related compounds in age-related diseases or as a preventive reagent against the aging process.

Biography :

Email: jwkim@amorepacific.com