The pathophysiology of essential hypertension in young/middle-age, and treatment implications

12^th Global Nephrologists Annual Meeting

June 26-28, 2017 London, UK

John Malcolm Cruickshank

Cardiovascular Consultant (Self-employed), London

Posters & Accepted Abstracts: J Nephrol Ther

Abstract :

Essential hypertension is a major global risk factor for premature death. The Framingham Group have shown that the appearance of diastolic hypertension is linked to: a) Young/middle age, b) Obesity. Central obesity is associated with high sympathetic nerve activity (SNA) (via high blood insulin/leptin levels acting upon the hypothalamus). High SNA, independent of BP is associated with premature cardiovascular death in middle-age. Antihypertensive agents that increase SNA, e.g., diuretics, dihydropyridine calcium blockers, and ARBs, do not reduce (and may increase) the risk of cardiovascular death in younger/middle-aged hypertensive subjects. The first-line choice of antihypertensive drug in such cases should be either beta-blockade or ACE-I. Guide-line Committees around the world are confused on this issue.

Biography :

Email: Johndtl@aol.com