Dejan Popovic, Danka Sokolovic, Milorad Antic and Dusan Sokolovic
University of Nis, Serbia Institute for Blood Transfusion in Nis, Serbia
Posters & Accepted Abstracts: Chemical Sciences Journal
The protective activity of the anthocyanins from the bilberry extract in the acute liver damage in rats caused by CCl4 (1.5 mL/kg i.p.) was examined. The mechanism of the acute hepatotoxicity was based on an excessive production of the reactive metabolites CCl4, which led to the morphological liver cells damage through the lipid peroxidation induction and oxidative stress. The membrane damage caused the enzyme leakage from the hepatocytes and increased activity of AST and ALT in the serum. The acute CCl4 poisoning resulted in a significant increase of the pro-oxidative (MDA and GSSG) and a decrease of the anti-oxidative (GSH, CAT, SOD, GST, GPx, and GR) markers in the liver. The CCl4 toxic effects caused the massive perivenular coagulation necrosis followed by micro and microvesicular fatty changes in the periportal region. The protective use of the bilberry extract (100 mg/kg of the oral ten-day treatment with anthocyanins) prior to the administration with the toxic CCl4 resulted in an evident decrease of the pro-oxidative markers, as well as a significant decrease of the dissipation of the liver anti-oxidative defence capacities in comparison to the results detected in the animals treated with CCl4 exclusively. The pathohistological changes were described as less serious reversible hydropic changes characterized by an evident absence of the necrosis. The protective effect of the anthocyanins was based on the neutralization of the highly reactive CCl4 metabolites by adding the hydrogen atom from the hydroxyl groups of delphinidin from the anthocyanin.
Dejan Popovic is from University of Nis, Serbia.
Chemical Sciences Journal received 912 citations as per Google Scholar report
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