The quest of new cancer models and their properties in the NGS era

10^th Global Annual Oncologists Meeting

July 11-13, 2016 Cologne, Germany

Ugo Rovigatti

University of Florence Medical School, Italy

Posters & Accepted Abstracts: J Cancer Sci Ther

Abstract :

It is today indisputable that great progresses have been made in our molecular understanding of cancer cells but an effective implementation of such knowledge into dramatic cancer-cures is still belated and yet desperately needed. This review gives a snapshot at where we stand today in this search for cancer understanding and definitive treatments, how far we have progressed and what are the major obstacles we will have to overcome both technologically and for disease modeling. In the first part, promising 3rd/4th Generation Sequencing Technologies will be summarized (particularly Ion Torrent and Oxford Nanopore technologies). Cancer modeling will be then reviewed from its origin in XIX Century Germany to todayâ�?�?s NGS applications for cancer understanding and therapeutic interventions. Developments after Molecular Biology revolution (1953) are discussed as successions of three phases. The first, PH1, labeled â�?�?Clonal Outgrowthâ�? (from 1960s to mid 1980s) was characterized by discoveries in cytogenetics (Nowell, Rowley) and viral oncology (Dulbecco, Bishop, Varmus), which demonstrated clonality. Treatments were consequently dominated by a â�?�?cytotoxic eradicationâ�? strategy with chemotherapeutic agents. In PH2, (from the mid 1980s to our days) the description of cancer as â�?�?Gene Networksâ�? led to targeted-gene-therapies (TGTs). TGTs are the focus of Section 3: In view of their apparent failing (Ephemeral Therapies), alternative strategies will be discussed in review part II (particularly cancer immunotherapy (CIT). Additional Pitfalls impinge on the concepts of tumor heterogeneity (inter/intra; ITH). The described pitfalls set the basis for a new phase, PH3, which is called â�?�?NGS Eraâ�? and will be also discussed with ten emerging cancer models in the Review 2nd part..

Biography :

Email: profrovigatti@gmail.com