The role of glucocorticoid receptors in basolateral amygdala

International Conference and Exhibition on Molecular Medicine and Diagnostics

August 24-26, 2015 London, UK

Ghassem Attarzadeh Yazdi

Posters-Accepted Abstracts: J Mol Genet Med

Abstract :

Stress represents a wide range of physical responses and plays an important role in modulating different stages of memory including
reconsolidation. Relapse to drug taking induced by exposure to stimuli or cues associated with drugs of abuse is a main challenge
to the treatment of morphine addiction. We examined the effects of forced swim stress and corticosterone on reconsolidation of a
drug-related memory using a conditioned place preference (CPP) procedure. The results showed that animals acquired morphine
CPP after conditioning, and that this CPP was inhibited by stress given immediately after re-exposure to morphine. Corticosterone
injection which leads to immediate and sudden increase in the level of glucocorticoids fails to reinstate the terminated CPP in rats.
Studies on FSS-induced reinstatement show that this behavior is blocked by administration of corticotrophin-releasing hormone
(CRH) antagonists. Overall, these results suggest that corticosterone plays an important role in relapse to drug seeking behavior
induced by stress.

Biography :

Ghassem Attarzadeh Yazdi has completed his PhD at 2006 from University of Edinburgh. He has published more than 8 papers in different journals. He is doing fellow at
HUMS as a student at the moment and he would like to present his work in your conferences as poster.