The role of probiotics in the pathogenesis of metabolic disorders

7^th International Veterinary Congress

September 04-05, 2017 | Paris, France

Gulay Ciftci, Belgin Siriken, Berika Tastekin and Alper Ciftci

Ondokuz Mayis University, Turkey

Posters & Accepted Abstracts: J Vet Sci Technol

Abstract :

Metabolic disorders present an increasing public health concern and can significantly undermine an individualâ�?�?s quality of life. Over the last decade, dynamic changes in dietary nutrient ingestion have rapidly increased the prevalence of metabolic disorders. Recently, scientists have proposed that metabolic disorders might result from an alteration in gut microbiota composition. The term â�?�?probioticâ�? originates from the Greek word meaning â�?�?for lifeâ�?. In 1989, Fuller defined the term probiotic as â�?�?a live microbial feed supplement which beneficially affects the host animal by improving its intestinal balanceâ�?. It is well established that five bacterial phyla, firmicutes, bacteroidetes, actinobacteria, proteobacteria, and verrucomicrobia, are dominant components of the gut microbiota. More than 90% of the bacterial populations are gram-negative anaerobes and include the predominant genera bacteroides, eubacterium, bifidobacterium, and fusobacterium. Diet controls the composition of these bacteria, which are crucial in the development of metabolic disorders. Accumulating evidence suggests that supplementation of probiotics and prebiotics could have preventative and therapeutic effects on CVD due to a reduction in total serum cholesterol, low-density lipoprotein (LDL-cholesterol), and inflammation. In particular, changes of gutmicrobiota composition are strongly associated with increased adiposity, cell dysfunction, metabolic endotoxemia, systemic inflammation]. The change in intestinal microbiota and the reduced bacterial diversity were also observed in obese conditions. The change of these bacteria compositions increases susceptibility to infections, immune disorders, inflammation, oxidative stress and insulin resistance, events that are mediated by metabolic endotoxemia, which involves exposure to noxious intestinal products, particularly lipopolysaccharides. Consequently, the present review aimed to provide an objective perspective of the current knowledge regarding the impacts of food constituents on gut microbiota and health.

Biography :

Gulay Ciftci is an Expert in Molecular Biochemistry and Proteomics. She finished PhD at Ankara University, and now she works as an associate professor at Ondokuz Mayis University, Samsun, Turkey. She focuses on working hormones, proteins and genes.