Mavlyanova Shakhnoza Zakirovna and Alimova S M
Ministry of Health of the Republic of Uzbekistan, Uzbekistan
Scientific Tracks Abstracts: J Mol Genet Med
Aim: It is the study of polymorphism of genes of enzymes of biotransformation of xenobiotics in patients with
allergic skin diseases.
Material & Methods: Patients with allergic dermatoses (AlD), DNA samples of patients and healthy donors,
glutathione-transferase GSTM1 (1p13.3), GSTT1 (22q11.2) and IIe 105Val genes of the GSTP1 gene were
the object and subject of the study. The study included 88 patients with AlD age ranging from 5 to 67 years.
Of these, 41 are women, 50 are men. The diagnosis in all patients is confirmed by the results of the clinical
examination and laboratory tests.
Results: Among patients with allergic dermatoses, individuals with combined functionally inferior genotypes
GSTM10/0+GSTT10/0 were more common than in the group of healthy individuals (6.8% vs. 4.1%,
respectively, Ï?2=0.5; P=0.4; OR=1.7, 95% CI 0.405-6.979). The obtained data indicate that in individuals
with zero genotypes of genes of xenobiotic enzymes GSTM1 and GSTT1 there is a tendency to the risk of
allergic dermatosis development. Whereas, with the combined variants of zero and functional genotypes of
polymorphism of the GSTM1 and GSTT1 genes, there were no statistically significant differences between the
groups studied (p>0.05). While the frequency distribution of the occurrence of alleles and genotypes of GSTP1
in the group of patients with allergodermatosis, in comparison with the control group, significant differences
were found. The functionally unfavorable allele G of the GSTP1 gene was 3.4 times statistically significantly
more prevalent in the studied chromosomes of allergic dermatoses than in the population sample (Ï?2=10.8;
P<0.05; OR=3.4; 95% CI 1.6-7.4). The associations of functionally unfavorable A/G genotypes were identified
(Ï?2=6.9, P<0.05, OR=2.6, 95% CI 1.264-5.382) and G/G (Ï?2=8.0; P<0.05; OR=11.2; 95% CI 1.421-88.43) with
the development of allergic dermatoses.
Conclusion: Genes of glutathione transferase, polymorphism IIe 105 Val of the GSTP1 gene is the most
significant marker of an increased risk of allergic skin diseases in Uzbekistan.
Mavlyanova Shakhnoza Zakirovna received Doctor of Medical Sciences degree at the Higher Attestation Commission under the Cabinet of Ministers of the Republic of Uzbekistan. She is the Head of the Scientific Department of Dermatology of the Republican Specialized Scientific and Practical Medical Center of Dermatovenereology and Cosmetology, Ministry of Health of the Republic of Uzbekistan. She is a Member of the Association of Dermatovenereologists and Cosmetologists of the Republic of Uzbekistan and the European Academy of Dermatovenerologists. She has published over 300 articles in well-known journals, has 7 patents for inventions, 5 monographs and is also a Member of the Editorial Board of the Journal of Dermatovenereology and Cosmetology of Uzbekistan.
E-mail: shahnoza_m@mail.ru
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