Therapeutic and synthetic approach towards indazole

International Conference on Stereochemistry

August 18-19, 2016 Sao Paulo, Brazil

Digambar D Gaikwad

Government College of Arts & Science, Maharashtra, India

Posters & Accepted Abstracts: Med chem

Abstract :

Among the various heterocyclic compounds, indazoles form a privileged class of core skeleton with their diverse spectrum of therapeutic potential. The easy generation of complex molecular diversity is broadly applicable, cost effective, practical and sustainable. Synthetic methods in a straight forward fashion along with the importance of these motifs in biological and pharmaceutical applications received significant attention from researchers engaged in drug design. Fused 1H-indazole and 2H-indazole are well recognized for anti-hypertensive, anticancer properties antibacterial, anti-depressant and anti-inflammatory activities. New YC-1 indazole derivatives were synthesized and evaluated with HIF-1 transcriptional activity, in vivo. Furthermore, for the mechanistic study of the YC-1 derivatives, shows the anti-proliferative activity against human cancer cells and 1,3,5-trisustituted indazole derivative as an extremely potent antioxidant. The 7-nitro indazoles derivative was tested for the treatment of alcohol dependence, anti-mutagenesis and anti-oxidant properties. Similarly piperidine derivative of indazole has been patented as a non-narcotic, analgesic and antipsychotic drug. The indazole ring system is also present in many other compounds such as herbicides, dyes and sweeteners. Granisetron, serotonin 5-HT3 receptor antagonist used is to treat and prevent nausea and vomiting induced by cancer chemotherapy. Pan-Kinase inhibitor anthrapyrazolone is rationally used for designing of indazoles based potent of cell-active Mps1 kinase inhibitors. The new paradigm is to develop eco-friendly and green procedures for the construction of bioactive indazole compounds in order to help medicinal chemists in designing and synthesizing novel and potent compounds for the treatment of different disorders.

Biography :

Email: gaikwad_dd@yahoo.com