Therapeutic Profile of Stroke Patients Managed with Neuroprotective Regimens

13^th International Conference on Stroke, Neurology and Cerebrovascular Diseases

June 20-21, 2022 | Webinar

Mayuri Tuwar, Chyi-Huey Bai

School of Public Health, College of Public Health, Taipei Medical University, Taiwan
School of Medicine, College of Medicine, Taipei Medical University, Taiwan

Scientific Tracks Abstracts: J Neurol Disord

Abstract :

TSPO is known to be found in arterial plaques, which are a symptom of atherosclerosis and a contributory cause of ischemic stroke. BDNF is unique among neurotrophins in that it has a high level of expression in the brain and has significant synaptic effects. This study aims to determine the diagnostic accuracy of plasma TSPO and BDNF, levels in discriminating new-onset ischemic stroke patients from the healthy controls. We measured two controls without a history of stroke or any neurodegenerative disease were age and gender-matched with each case. Cases were patients with firstever stroke (neurologist’s clinical definition) admitted to the stroke unit within 48 hours of symptom onset. TSPO and BDNF were measured by enzyme-linked immunosorbent assay (ELISA). Logistic regression was used to investigate the association between high serum TSPO levels and having AIS in the matched design. Additionally, a receiver operating curve (ROC) analysis was used to study the diagnostic performance of TSPO and BDNF for AIS. AIS patients had significantly higher TSPO and BDNF levels in blood pressure, glycosylated hemoglobin, white blood cells, and creatinine than controls. The association is still significant after adjusting for age, gender, comorbidities (HTN, DM,) and biomarkers ((BUN, Creatinine, HDL, LDL, and hs-CRP). TSPO and BDNF significantly discriminated AIS patients from healthy controls (AUC 0.89, and AUC 0.75, respectively). Our study found that Serum TSPO and BDNF levels distinguished AIS patients from healthy controls. In patients with acute ischemic stroke at admission, increased serum TSPO and BDNF levels could be utilized as a potential diagnostic marker with good AUC as well as a promising predictor.

Biography :

Mayuri is currently a Ph.D. student in the public health department at Taipei Medical University. I received a B.S. from Maharashtra University of health science, India at Homoeopathic Medicine (BHMS), and an M.S. from Taipei Medical University at Public health. My research interest includes Ischemic stroke and biomarkers.