Ghizal Fatima, Abbas Ali Mahdi and Siddharth Kumar Das
King George�s Medical University, India
Posters-Accepted Abstracts: J Mol Biomark Diagn
Objective: In the present study we examined the involvement of oxidative stress in women with Fibromyalgia Syndrome (FMS) and also evaluated its correlation with the severity of its symptoms. Introduction: FMS is a common chronic pain syndrome with an unknown etiology. Increased oxidative stress results from an imbalance between products of oxidation and antioxidant defenses. There are several clinical conditions associated with increased oxidative stress, but novel data suggest a relationship between oxidative stress and pain perception. Furthermore, there is little information available in scientific literature about oxidative stress in FMS. Methods: Oxidative stress was determined by measuring the levels of Lipid Peroxides (LPO) and Protein carbonyl group in plasma in 30 female patients satisfying American College of Rheumatology (ACR) criteria for FMS and 30 healthy females without FMS. Clinical parameters of FMS were evaluated by Fibromyalgia Impact Questionnaire Revised (FIQR). Results: We found increased LPO and Protein carbonyl group in FMS patients as compared to control (p<0.01). A significant positive correlation was found between LPO and clinical symptoms of FMS among patients group. Furthermore, a significant positive correlation was also found between Protein carbonyl group and clinical symptoms of FMS among patients group in comparison to control group. Conclusion: The present results indicate that women with FMS are exposed to oxidative stress and this increased oxidative stress may play a role in the etiopathogenesis of the disease. Moreover, our results also show that increased oxidative stress parameters are more strongly associated with FMS symptoms.
Email: ghizalfatima8@gmail.com
Molecular Biomarkers & Diagnosis received 2054 citations as per Google Scholar report
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