Mark L Gordon
Millennium-TBI Network, USA
Posters & Accepted Abstracts: Altern Integr Med
The neuropsychological behavioral characteristics of any one individual are frequently perceived to be the results of environmental influences. The debate over â??nature and nurtureâ? pit our genome against the influences of our environment in that, we are who we are based upon the company we keep or is it the genes we express? Neuroplasticity under the control of genes and regulated by the hormones that bathe our cerebral lobes appears to have both genomic and epigenomic influences on how we respond to a variety of environmental challenges. Whether-or-not it is nurture or nature. The neuropsychopharmacology of hormones is an expanding field showing us that the regulation of reactive emotions from the limbic system is due in part to changes in the gated-ion channels of neurons and their receptors, thereby influencing our intelligence and emotional presence. It is through the modulation of receptors such as GABAA, GABAB, NMDA, Sigma-1, and AMPA that a group of hormones produced in the brain and referred to as Neurosteroids influence who and what we are perceived to be and are in the moment. The most influential neurosteroids are those that not only regulate receptors, but also the health and regeneration of neurons. Representatives of this classification are progesterone, allopregnanolone, estradiol, testosterone, dihydrotestosterone, pregnenolone and their active sulfated forms all manufactured de novo in the brain. It is the absolute or relative loss of these neurosteroids or a sudden and precipitous change in their relative balances that can lead to alterations in how we react and how we manage our mental well-being. This presentation will walk the audience through a number of published peer-reviewed articles that provides the science behind a cost-effective, alternative approach to the treatment of TBI and PTSD.
Alternative & Integrative Medicine received 476 citations as per Google Scholar report
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