Treatment outcomes of direct-acting antiviral therapy among chronic kidney disease and post kidney transplant patients with hepatitis C virus infection: Single center experience

15^th World Nephrology Conference

May 20-21, 2019 Tokyo, Japan

Shena Jo A Capucion

National Kidney and Transplant Institute, Philippines

Scientific Tracks Abstracts: J Nephrol Ther

Abstract :

Background & Aim: Hepatitis C Virus (HCV) infection is common among Chronic Kidney Disease (CKD) and kidney transplant recipients. Direct Acting Antiviral (DAA) regimens has been demonstrated to be effective with high Sustained Virological Response (SVR) rates and tolerated in the general population. Data is limited and remains to be confirmed among CKD and kidney transplant recipients. The study aims to investigate treatment outcomes of DAA therapy among CKD and kidney transplant patients with hepatitis C infection. Specifically, it seeks to describe demographics, determine SVR rates, changes in laboratory values and adverse effects with DAA therapy.

Methods: The study employed a retrospective observational study design. It included all cases of CKD and kidney transplant recipients with chronic HCV infection who are â?¥18 year old on DAA Therapy at National Kidney and Transplant Institute, Philippines from December 2015 to December 2016. Descriptive analysis of treatment outcomes, changes in laboratory values and adverse events.

Result: 12 patients were included, 7 (58%) CKD and 5 (42%) kidney transplant recipients. All patients (100%) had SVR 12. Changes in laboratory values during treatment included: (1) Mean increase in creatinine of 0.3 mg/dL vs. 0.04 mg/dL; and (2) Mean decline in hemoglobin of 2 mg/dL vs. 1.5 mg/dL, in platelet of 18�103/μL vs. 7�103/μL, in ALT levels of 31 U/L vs. 27 U/L and in bilirubin 0.5 mg/dL vs. 0.12 mg/dL in CKD and post kidney transplant recipients respectively. One (8.3%) kidney transplant recipient had disorientation but did not lead to treatment discontinuation.

Conclusion: Our study showed an SVR12 rate of 100% in both CKD and kidney transplant recipients. Majority did not experience adverse effects during treatment. Further larger studies are needed to validate our findings.

Biography :

Shena Jo A Capucion has obtained her Bachelor of Science in Biology from the University of the Philippines. She has attended Medical school and earned her MD from Remedios Trinidad Romualdez Medical Foundation, Tacloban City, Philippines. She has then completed her Residency in Internal Medicine at National Kidney and Transplant Institute, Philippines. She is currently a Senior Adult Nephrology Fellow-in-Training in the same institution.

E-mail: shenajocapucion_md@yahoo.com