Tumor markers: Quality control of the laboratory analyses: Importance and benefits

24^th World Nursing and Healthcare Conference

September 13-15, 2018 | Copenhagen, Denmark

Jana Slobodnikova, Katarina Kaslikova, Miroslava Hazuchova, Miroslav Cernicky, Zdenka Krajcovicova and Vladimir Melus

Alexander Dubcek University of Trencin, Slovakia
St. Elizabeth University of Health and Social Work, Slovakia

Posters & Accepted Abstracts: Adv Practice Nurs

Abstract :

Background: Tumor markers are important tools in laboratory diagnostics of cancer diseases, which allows us continual supervision of patients´ stage and its time-dynamics. Thanks to these laboratory parameters, receiving diseases can be treated significantly earlier. In our study we evaluated routinely tested tumor markers CA125, Ca199, CEA, PSA, AFP, HCG and Ca153 with emphasis on their diagnostic value in clinical practice. Aim: The goal of our preliminary study is to verify the informational quality of tested parameters in terms of precision, accuracy and reliability of results with the aim of the external quality control (EQC). Material & Methods: All listed tumor markers were determined by laboratory methods based on the principle of electrochemiluminescence. The anonymous material for the analysis was provided by a supplier of the external quality control in the form of sample pairs with an undisclosed concentration of the analyte. After processing there were obtained concentrations of particular analytes and they were sent back to the supplier of external quality control for evaluation. Acceptable outcomes were cut-off values which didn´t exceed 20% of the CV of the group, to which laboratory methodologically belonged. Results: Based on the results it can be concluded that in the tested period laboratory succeeded in all measured parameters, while the critical difference was not even once exceeded. This is primarily about the robustness and reliability of the methodology and laboratory analyzers. It was therefore not necessary even once implemented corrective measures that would inevitably followed the findings of non-compliance. Despite these results, it should be noted, that laboratory diagnostics of tumor markers is timecontinuous stream of samples, materials and information, during which there may be in non-compliance at any time. Conclusion: It is necessary to understand that the external quality control is continuous process of systematic activities directed to the improvement of laboratory work.

Biography :

Jana Slobodnikova has completed her PhD at the Institute of Experimental Oncology Slovac Scientic Academy, Slovakia. She worked as Assistant Proffessor at Trnaviensis University and Proffessor Emeritus at St. Elizabeth High School. She has lectured at several universities in Prague, Trenčín, Trnava and Bratislava. She is the author of teaching script, university textbooks, and she leads workshops, organizes international congresses and workshops. She has published more than 90 scientific papers, 25 papers in renomed journals and has been serving as an Editorial Board Member of five reputed journals. She has published three monographies. She has founded the Section of Breast Imaging in 1996; from 1996 - President of The Section of Breast Imaging of Slovak Radiologic Society and Vice President of the Slovak Society of Ultrasound in Medicine. She has Membership in organizations such as ECR, EUSOBI, EFSUMB , SSUM ( Slovak Society of Ultrasound in Medicine ) and SRS ( Slovak Radiology Society).