Vitamin D and congenital ichthyosis: A case series in India

23^rd Asia-Pacific Dermatology Conference

October 26-28, 2017 Osaka, Japan

Priyanka Hemrajani

Kempegowda Institute of Medical Sciences, India

Posters & Accepted Abstracts: J Pigment Disord

Abstract :

Introduction: Ichthyosis, a genetic disorder of keratinization is characterized by excessive scaling associated with epidermal hyper proliferation and/or cellular retention. Normally, thickness of the outer epidermis is 25 ���µm and that of a patient of ichthyosis is 10 folds greater. This impairs photo activation of 7-dehydrocholesterol and causes systemic vitamin D deficiency. Materials & Method: This was a prospective observational study performed at Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka, India. Patient�¢����s clinical characteristics were recorded. Serum concentration of 25-hydroxyvitamin D was determined along with serum calcium, phosphorus and parathyroid hormone. X-rays of the bilateral wrists and knee joints in antero-posterior and lateral views were done. It is a case series of 12 patients with vitamin D deficiency correlating with calcium, phosphorus, parathyroid hormone levels and radiological findings. Results: Out of 12 patients of congenital ichthyosis, 6 were males and 6 females. Out of these 12, only 2 had vitamin D sufficiency. For 10 patients with vitamin D below the optimal level (<30 ng/ml), following are the tested vitamin D levels: (1) Vitamin D>20 ng/ml but <30 ng/ml-2 patients, (2) Vitamin D >10 ng/ml but <20 ng/ml-2 patients and (3) Vitamin D <10 ng/ml-6 patients. Serum calcium and phosphorus were normal for all patients. Only 2 patients had hyperparathyroidism. Radiologically, 2 patients had Genu valgum and 1 patient had Rickets. Conclusion: Vitamin D plays a vital role in patients of congenital ichthyosis and it should be tested for every patient of congenital ichthyosis as it would help in better prognosis and management of the patients.