Friday E Uboh, Saviour U Ufot and Uduak O Luke
University of Calabar, Nigeria
University of Uyo Teaching Hospital, Nigeria
Posters & Accepted Abstracts: J Environ Anal Toxicol
Haematotoxicity has been reported to be associated with exposure to endosulfan, but whether withdrawal from exposure can reverse the toxicity effect have not been well established. This study assessed the effect of withdrawal from exposure on sub-chronic endosulfan exposure induced haematotoxicity in rats. Sixty rats (weighing 100-110 g), divided into six groups of ten rats each, were used in this study. The rats were respectively exposed orally to 0.0, 1.0, 2.0, 3.0, 4.0 and 5.0 mg/kg/day of endosulfan for 30 days (6 days/week). After 30 days of exposure, five rats from the respective groups were sacrificed and the blood sample collected for hematological assay. The remaining five rats in each of the respective groups were withdrawn from exposure for the next 30 days before sacrificing them for hematological assay. The result of the study showed that sub-chronic exposure to endosulfan caused a significant (p â?¤ 0.05) decrease in packed cell volume (PCV), haemoglobin (hb) concentrations and red blood cells (rbc) counts, as well as increase in total and some differential white blood cells (wbc) counts in a dosedependent pattern, compared with the control. This indicated sub-chronic endosulfan exposure induced haematotoxicity. However, withdrawal from exposure was observed to significantly reverse the endosulfan-altered levels of PCV, hb, rbc, as well as total and differential wbc counts to the levels within the control range. This observation gave an indication that the haematotoxic effect associated with sub-chronic exposure to endosulfan may be reversed after withdrawal from the exposure for about the equivalent duration of exposure in rats.
E-mail: fridayuboh@yahoo.com
Environmental & Analytical Toxicology received 6818 citations as per Google Scholar report
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