TR Harring, NT Nguyen, JA Goss and CA Oââ¬â¢Mahony
Introduction: The human T cell lymphoma virus was screened for previously in organ donors secondary to concern for progressive disease in an immunocompromised host. However, due to the low prevalence of the virus, a shortage of suitable allografts, and the lack of a time effective test, this practice has been abandoned in the United States. The human T cell lymphoma virus type I may cause progression to several diseases, including human T cell lymphoma virus associated myelopathy, and adult T cell lymphoma/l eukemia. Moreover, there is an overall lack of data relating to the safety profile in the medical literature with use of human T cell lymphoma virus positive allografts.
Aim: To determine the safety of human T cell lymphoma virus positive allografts in orthotopic liver transplantation.
Materials and Methods: Our database was queried for recipients of known human T cell lymphoma virus positive allografts at time of transplantation. We present one patient case report followed by a review of the medical literature.
Results: The patient was transplanted secondary to cirrhosis due to alcohol and hepatitis C virus infection with hepatocellular carcinoma. When a suitable allograft became available, the patient was advised that it was human T cell lymphoma virus type I positive. The risks and benefits were discussed thoroughly with the patient and he elected to proceed with the operation. His operation and post operative course were unremarkable. He continues to do well during on follow up of over 777 day s, and currently he has no symptoms of any human T cell lymphoma virus associated disease. Review of the medical literature demonstrates few reports on human T cell lymphoma virus related complications after orthotopic liver transplantation; however, the re are theories that immunosuppresion may cause progressive disease in these patients.
Conclusions: Human T cell lymphoma virus type I positive donors can be life saving sources of allografts. Our center supports the use of these allografts in patients that otherwise continue to be on the waiting list.
Nursaheker
DOI: 10.37421/2161-0991.2024.14.267
Organ transplantation is a life-saving medical procedure for patients with end-stage organ failure. However, despite significant advancements in transplantation medicine, graft rejection remains a major obstacle to successful transplant outcomes. The immune system plays a critical role in recognizing and eliminating foreign tissue, leading to immunological challenges that contribute to graft rejection. This research article aims to review the existing literature on the immunological aspects of transplantation and discuss strategies for enhancing graft survival. By understanding the underlying mechanisms of immune response and developing novel approaches to modulate the immune system, we can pave the way for improved transplantation outcomes and ultimately enhance patients' quality of life.
DOI: 10.37421/2161-0991.2024.14.268
DOI: 10.37421/2161-0991.2024.14.269
DOI: 10.37421/2161-0991.2024.14.270
DOI: 10.37421/2161-0991.2024.14.271
Tissue engineering has emerged as a revolutionary field in transplantation research, aiming to overcome the limitations of traditional organ transplantation. This article provides a comprehensive review of the literature on tissue engineering, focusing on recent breakthroughs, advancements, and challenges. We discuss the potential impact of tissue engineering in transforming the landscape of transplantation, offering hope for patients in need of organ and tissue replacements. The article concludes by highlighting the promising future prospects and implications of tissue engineering in the field of transplantation.
Organ transplantation has long been considered the gold standard for treating end-stage organ failure and irreparably damaged tissues. Despite its life-saving potential, traditional organ transplantation faces numerous challenges, including the scarcity of donor organs, the risk of organ rejection, and the need for lifelong immunosuppression. These limitations have spurred the emergence of tissue engineering as a revolutionary field in transplantation research, offering a promising alternative to conventional transplantation methods.
DOI: 10.37421/2161-0991.2024.14.272
Organ transplantation has undergone significant advancements and witnessed breakthroughs in recent years, leading to improved patient outcomes and expanding the possibilities for successful transplantation. This mini-review provides an overview of the key innovations in organ transplantation. It explores advancements in organ preservation techniques, such as machine perfusion systems that mimic the human body's conditions, enhancing organ viability. Immune system modulation has also seen progress with the development of more targeted and effective immunosuppressive drugs and personalized cellular therapies. The field of organ bioengineering and regenerative medicine offers hope for overcoming the organ shortage by creating functional organs using bioengineering techniques and stem cell technologies. Xenotransplantation, the transplantation of organs between species, has become more viable due to genetic engineering and immunomodulation advancements. Additionally, artificial organs and assist devices have improved the quality of life for patients awaiting transplantation or ineligible for organ transplantation.
DOI: 10.37421/2161-0991.2024.14.273
DOI: 10.37421/2161-0991.2024.14.274
DOI: 10.37421/2161-0991.2024.14.275
Transplantation research has been at the forefront of medical advancements, revolutionizing the treatment of end-stage organ failure. In recent years, the field has witnessed the integration of emerging technologies, enabling groundbreaking achievements and unlocking new avenues for transplantation. This article provides an overview of the current state of transplantation research and explores the potential of emerging technologies in enhancing donor availability, improving organ preservation, and optimizing patient outcomes. It also discusses the ethical considerations and challenges associated with these advancements. By harnessing the power of emerging technologies, transplantation research is poised to deliver transformative solutions and redefine the future of organ transplantation.
Transplantation Technologies & Research received 223 citations as per Google Scholar report
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